Relating Form and Function of EF-Hand Calcium Binding Proteins
نویسندگان
چکیده
منابع مشابه
EF-hand calcium-binding proteins.
The EF-hand motif is the most common calcium-binding motif found in proteins. Several high-resolution structures containing different metal ions bound to EF-hand sites have given new insight into the modulation of their binding affinities. Recently determined structures of members of several newly identified protein families that contain the EF-hand motif in some of their domains, as well as of...
متن کاملPrediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins.
The EF-hand protein with a helix-loop-helix Ca(2+) binding motif constitutes one of the largest protein families and is involved in numerous biological processes. To facilitate the understanding of the role of Ca(2+) in biological systems using genomic information, we report, herein, our improvement on the pattern search method for the identification of EF-hand and EF-like Ca(2+)-binding protei...
متن کاملPrediction of EF-hand calcium-binding proteins and identification of calcium-binding regions using machine learning techniques
Predicting calcium binding proteins and identifying calcium-binding sites is an important problem in the field of proteomics. Most of the currently used methods employ structural protein data to predict calcium-binding sites. Here we present a method developed to predict calcium-binding proteins and identify calcium-binding sites from protein sequence data using machine learning techniques such...
متن کاملMolecular Tuning of an EF-Hand-like Calcium Binding Loop
Calcium binding and signaling orchestrate a wide variety of essential cellular functions, many of which employ the EF-hand Ca2+ binding motif. The ion binding parameters of this motif are controlled, in part, by the structure of its Ca2+ binding loop, termed the EF-loop. The EF-loops of different proteins are carefully specialized, or fine-tuned, to yield optimized Ca2+ binding parameters for t...
متن کاملThe gene family of EF-hand calcium-binding proteins from the flagellum of Trypanosoma brucei.
The flagellum of Trypanosoma brucei contains calmodulin, and a separate family of antigenically related EF-hand calcium-binding proteins which we call calflagins. The following study evaluates the structure and genomic organization of the calflagin family. Genomic Southern blots indicated that multiple copies of calflagin genes occurred in T. brucei, and that all of these copies were contained ...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2011
ISSN: 0001-4842,1520-4898
DOI: 10.1021/ar100110d